Endocrine Abstracts

Persistence of elevated TSH levels despite large doses of L-thyroxin is not uncommon, although thyroxin substitution is usually easy and convenient. The first cause to be considered is thyroxin malabsorption, whether organic, due to concomitant gastric or intestinal disease, or bariatric surgery, or, more frequently, related to dietary or drug interference. Proton-pump inhibitors, antacids and a long list of drugs may decrease thyroxin absorption. Drugs and thyr...